Marko Klisovic, MD

Assistant Professor

Department of Gynecology and Obstetrics, General Ob/Gyn

Office: Emory University Hospital Midtown, Medical Office Tower, 8th Floor

Phone: 404-778-3401

Biography

Education & Training   

Medical Education: University of Zagreb School of Medicine, Zagreb, Croatia, 2000
Residency: The Ohio State University, Obstetrics and Gynecology, 2008


Certifications 

American Board of Obstetrics and Gynecology, Obstetrics and Gynecology, 2009


Awards and Honors

•  The American College of Obstetricians and Gynecologists CREOG National Faculty Award in Resident Education in Ob/Gyn, 2017
•  John Boutselis, MD, Teaching Award, Department of Obstetrics and Gynecology, Mount Carmel Health and Ob/Gyn Residency at The Ohio State University, 2014, 2015, 2017
•  Award for Overall Best Medical Student in Class of 2000, School of Medicine, University of Zagreb, 2000
•  International Scholarship, Austria's Rotary Club for Best Medical Student, 1999
•  Dean's Award for Best Medical Student, School of Medicine, University of Zagreb, 1999


Society & Professional Memberships  

•  American Board of Obsetrics and Gynecology
•  American Congress of Obstetricians and Gynecologists
•  American Medical Association

Research

Publications

Klisovic RB, Stock W, Cataland S, Klisovic MI, Liu S, Blum W, Green M, Odenike O, Godley L, Vanden Burgt J, Van Laar E, Cullen M, Byrd JC, Marcucci G. A Phase I Biologic Study of MG98, an oligodeoxynucleotide antisense to DNA metyltransferase I, in Patients with High Risk Myelodysplasia and Acute Myeloid Leukemia. Clin Cancer Res. 2008 Apr 15. 


Klisovic DD, Klisovic MI, Effron D, Liu S, Marcucci G, Katz SE, Dipepsipeptide inhibits migration of primary and metastatic human uveal melanoma cell lines in vitro: a potential strategy for uveal melanoma. Melanoma Res. 15(3):147-53. 2005.


Dai G, Chan KK, Liu S, Hoyt D, Whitman S, Klisovic MI, Shen T, Caligiuri MA, Byrd J, Grever M, Marcucci G. Cellular update and intracellular levels of bcl2-antisense G3139 in cultured cells and treated patients with acute myeloid leukemia. Clin Cancer Res. 11(8):2998-3008. 2005.


Marcucci G, Stock W, Dai G, Klisovic RB, Liu S, Klisovic MI, Blum W, Kefauver C, Sher DA, Green M, Moran M, Maharry K, Novic S, Bloomfield CD, Zweibel A, Larson RA, Grever MR, Byrd JC. Phase I Study of Oblimersen Sodium, an Antisense to Bcl-2, in Untreated Older Patients with Acute Myeloid Leukemia: Pharacokinetics, Pharmacodynamics, and Clinical Activity. J Clin Oncol. 23(15):1-7. 2005.


Whitman SP, Liu S, Vukosavljevic T, Rush LJ, Yu L, Liu C, Klisovic MI, Maharry K, Guimond M, Strout MP, Becknell B, Dorrance A, Klisovic RB. Plass C, Bloomfield CD, Marcucci G, Caligiuri MA. The MLL partial tandem duplication: Evidence for recessive gain-of-function in acute myeloid leukemia identifies a novel patient subgroup for molecular targeted therapy. Blood 106(1): 345-52. 2005.


Liu S, Shen T, Huynh L, Klisovic MI, Rush LJ, Ford JL, Yu J, Becknell B, Li Y, Liu C, Vukosavljevic T, Whitman SP, Chang KS, Byrd JC, Perrotti D, Plass C, Marcucci G. Interplay of RUNX1/MTG8 and DNA methyltransferase 1 in acute myeloid leukemia. Cancer Res. 65(4): 1277-84, 2005.


Marcucci G, Stock W, Dai G, Klisovic MI, Maharry K, Shen T, Liu S, Sher DA, Lucas D, Zweibel A, Larson RA, Caligiuri MA, Bloomfield CD, Chan KK, Grever MR, Byrd JC. G3139, a BCL-2 antisense oligo-nucleotide, in AML. Ann Hematol. 83 Suppl 1:S93-4. 2004.


Zhang L, Freitas MA, Wickham J, Parthun MR, Klisovic MI, Marcucci G, Byrd JC. Differential expression of histone post-transitional modifications in acute myeloid and chronic lymphocytic leukemia determined by high-pressure liquid chromatography and mass spectrometry. J Am Soc Mass Spectrom. 15(1): 77-86. 2004.


Auer H, Lyianarachchi S, Newsom D, Klisovic MI, Marcucci G, Kornacker K. Chipping away at the chip bias: RNA degradation in microarray analysis. Nat Genet. 35(4): 292-3. 2004.


Klisovic DD, Katz SE, Effron D, Klisovic MI, Wickham J, Parthun MR, Guimond M, Marcucci G. Depsipeptide (FR 901228) inhibits proliferation and induces apoptosis in primary and metastatic uveal melanoma cell lines in vitro. Invest Ophthalmol Vis Sci. 44(6):2390-8. 2003.


Klisovic MI, Maghraby EA, Parthun MR, Guimond M, Sklenar RA, Whitman SP, Chan KK, Murphy T, Anon J, Archer KJ, Rush LJ, Plass C, Grever MR, Byrd JC, Marcucci G. Depsipeptide (FR 901228) promotes histone acetylation, gene transcription, apoptosis and its activity is enhanced by DNA methyltransferase inhibitors in AML1-ETO positive leukemic cells. Leukemia. 17(2):350-8. 2003.


Marcucci G, Byrd JC, Dai G, Klisovic MI, Kourlas PJ, Young DC, Cataland SR, Fisher DB, Lucas D, Chan KK, Porcu P, Lin ZP, Farag SR, Frankel SR, Zwiebel JA, Kraut EH, Balcerzak SP, Bloomfield CD, Grever MR, Caligiuri MA. Phase 1 and pharmacodynamics studies of G3139, a Bcl2-antisense oligonucleotide, in combination with chemotherapy in refractory or relapsed acute leukemia. Blood 101(2):425-32. 2003.


Abstracts

Whitman SP, Liu S, Klisovic MI, Vukosavljevic T, Guimond M, Rush LJ, Ruppert AS, Strout MP, Becknell B, Dorrance AM, Bruner RJ, Plass C, Bloomfield CD, Marcucci G, Caligiuri MA. Activation of the Silenced MLL (ALL-1) Wild-Type Allele in Acute Myeloid Leukemia (AML) with the Partial Tandem Duplication Results in Enhancement of Cell Death. Blood 102:11; p221a. 2003.


Liu S, Shen T, Rush LJ, Becknell B, Klisovic MI, Whitman SP, Vukosavljevic T, Byrd JC, Plass C, and Marcucci G. AML1/ETO Associates with DNA Metyltransferase 1(DNMT1) in Inducing Transcriptional Repression of the AML1-Target Gene Interleukin-3 (IL-3). Blood 102:11; p218a. 2003.


Liu S. Shen T, Rush LJ, Klisovic MI, Becknell B, Marcucci G. Depsipeptide (FR228), An Inhabitor of Histone Deacetylase Activity, Induces Proliferation Arrest and Apoptosis in Acute Myeloid Leukemia Cells Possibly Through Down-regulation of RhoA and Its Upstream Regulator LARG. Blood 102:11; p214b. 2003.


VanDeusen JB, Yu L, Biaser BW, Mao C, Guimond M, LeBeau MM, Klisovic MI, Marcucci G, Plass C, Caligiuri M. Characterization and DNA methyltransferase inhibitor treatment of primary murine T/NK acute lymphoblastic leukemia (ALL). Blood 102:11; p627a. 2003.


Marcucci G, Stock W, Zweibel JA, Cataland SR, Moran M, Lucas D, Liu S, Klisovic MI, Kefauver C, Green M, Chan KK, Frankel SR, Grever MR, Byrd JC. Clinical activity of Genasense (GNS, Oblimersen Sodium), a pro-apoptotic to Bcl-2 oligonucleotide, in combination with daunorubicin and cytarabine: A phase I study in previously untreated elderly aculte myeloid leukemia (AML). Blood 102:11; p385a. 2003.


Marcucci G, Dai G, Klisovic MI, Shen T, Liu S, Sher DA, Lucas D, Whitman SP, Vukosavljevic T, Zweibel JA, Frankel SR, Grever MR, Stock W, Chan KK, Byrd JC. Pharmacologic and biologic assessment of Genasense (GNS, Oblimersen Sodium), a pro-apoptotic to Bcl-2 oligonucleotide, in combination with daunorubicin and cytarabine: A phase I study in previously untreated elderly aculte myeloid leukemia (AML). Blood 102:11; p874a. 2003.


Klisovic MI, Klisovic DD, Katz SE, Effron D, Marcucci G. Depsipeptide (DP), histone deacetylase inhibitor (HDACI), inhibits migration of primary and metastatic uveal melanoma (UM) cells by down-regulation of matrix metalloproteinase (MMP) 2 and 9 gene expression. Invest Ophthalmol Vis Sci. 44: E-Abstract 1563.


Klisovic DD, Klisovic MI, Katz SE, Effron D, Wickham J, Parthun MR, Guimond M, Marcucci G. Histone deacetylase inhibitors (HDACIs) inhibit proliferation and induce apoptosis of primary and metastatic uveal melanoma cell lines in vitro: a potential therapeutic strategy for uveal melanoma (UM). Invest Ophthalmol Vis Sci. 44: E-Abstract 4977.


Whitman SP, Marcucci G, Klisovic MI, Bruner RJ, Liu S, Vukosavljevic T, Rush LJ, Plass C, Caligiuri MA. Activation of the silenced MLL (ALL1) wild-type allele in acute myeloid leukemia with the MLL partial tandem duplication by pharmacological inhibitors of DNA methyltransferase and histone deacetylase. AACR. 2003.


Marcucci G, Stock W, Klisovic MI, Guimond M, Sher D, Cataland SR, Fisher DB, Kefauver C, Chan KK, Frankel SR, Bloomfield CD. Caligiuri MA, Grever MR, Byrd JC. In vivo biological activity of Genasense ™ (G3139, Genta Inc) (GS), a Bcl-2 antisense in previously untreated patients with acute myeloid leukemia (AML) ≥ 60 years: A phase I study. Blood. 100:11;p337a. 2002.


Whitman SP, Guimond M, Blaser B, Klisovic MI, Vukosavljevic T, Bruner RJ, Ruppert AS, Becknell B, Barbosa X, Griffin J, Briewitz R, Caliguiri MA. Primary acute myeloid leukemia (AML) cells with the FLT3 internal tandem duplication (ITD) and absence of normal FLT3 (FLT3ITD/-Genotype) are distinct from AML with either FLT3WT/WT or FLT3ITD/WT genotypes. Blood. 100:11; p89a. 2002.


Magrhraby EA, Murphy T, Parthun MR, Klisovic MI, Sklenar A, Archer KJ, Whitman S, Grever MR, Caligiuri MA, Byrd JC, Marcucci G. Depsipeptide (FR901228) induces lysine-specific histone acetylation, differentiation and apoptosis in acute myeloid leukemia cells and demonstrates synergy with decitabine. Blood 98:11; p103. 2001.


Marcucci G, Byrd JC, Cataland SR, Fisher DB, Lucas D, Chan KK, Klisovic MI, Young DC, Didier LA, Balcerzak SP, Frankel SR, Kraut EH, Bloomfield CD, Grever MR, Caligiuri MA. Clinical and biological activity of Genasense ™ (G3139, Genta, Inc.), a bcl-2 antisense in refractory or relapsed acute leukemia: a phase I study. Blood 98:11; p216. 2001.


Klisovic MI, Mrsic S, Mrsic M, Boban D, Batinic, Zadro R. Cytogenetic findings in patients with chronic myelogenous leukemias in transformation. Second European Meeting for Medical Genetics, Zagreb, Croatia, 1998.