Augustine Rajakumar, PhD - Assistant Professor

Augustine Rajakumar

Research

Video bio

Education & Training   


Graduate Education: 

Madurai Kamaraj University (Madurai, India), Integrated Biology, MSc, 1979

Madurai Kamaraj University (Madurai, India,) Cell and Molecular Biology, PhD, 1985

Postgraduate Training:

Biochemistry, McMaster University, 1987

Molecular Microbiology and Immunology, St. Louis University, 1987-1991

Pediatric Research Institute, St. Louis University, 1991-1995

Previous Academic Appointments


Assistant Professor, Pediatrics, Magee Womens Research Institute, University of Pittsburgh School of Medicine, 1995-1998

Assistant Professor, Obstetrics and Gynecology, Magee Womens Research Institute, University of Pittsburgh School of Medicine, 1998-2009

Instructor, Harvard Medical School, 2009-2014

Staff Scientist, Beth Israel Deaconess Medical Center, 2009-2014

Research Specialist III, Howard Hughes Medical Institute, 2009-2014

Society & Professional Memberships


•  Society for Gynecological Investigations


Emory University School of Medicine
Department of Gynecology and Obstetrics
1639 Pierce Drive, WMB 4208
Atlanta, GA, 30322

•  Placental health
•  Placental development
•  Placental pathology
•  Preeclampsia


Articles

Rimawi BH, Johnson E, Rajakumar A, Tao S, Jiang Y, Gillespie S, Schinazi RF, Mirochnick M, Badell ML, Chakraborty R. Pharmacokinetics and Placental Transfer of Elvitegravir and Dolutegravir, and Other Antiretrovirals during Pregnancy. Antimicrob Agents Chemother. 2017 Mar 27. pii: AAC.02213-16. doi: 10.1128/AAC.02213-16. [Epub ahead of print] PMID: 28348149


Augusto Korkes H, Oliveira. L, Sass N, Salahuddin S, Karumanchi SA, Rajakumar A. Relationship between hypoxia and downstream pathogenic pathways in preeclampsia. Hypertens Pregnancy. 2017 Jan 9:1-6. doi: 10.1080/10641955.2016.1259627. [Epub ahead of print] PMID: 28067578


Nadkarni NA, Rajakumar A, Mokhashi N, Burke SD, Rana, S, Salahuddin S, Dang Q, Thadhani R, Krishnan R, Stossel TP, Karumanchi SA. Gelsolin is an endogenous inhibitor of syncytiotrophoblast extracellular vesicle shedding in pregnancy. Pregnancy Hypertens. 2016 Oct;6(4):333-339. doi: 10.1016/j.preghy.2016.07.003. PMID: 27939478


Zsengeller ZK, Rajakumar A, Hunter JT, Salahuddin S, Rana S, Stillman IE, Ananth Karumanchi S. Trophoblast mitochondrial function is impaired in preeclampsia and correlates negatively with the expression of soluble fms-like tyrosine kinase 1. Pregnancy Hypertens. 2016 Oct;6(4):313-319. Doi: 10.1016/j.preghy.2016.06.004. PMID: 27939475


Cavalli RC, Cerdeira AS, Pernicone E, Korkes HA, Burke SD, Rajakumar A, Thadhani RI, Roberts DJ, Bhasin M, Karumanchi SA, Kopcow HD. Induced Human Decidual NK-Like Cells Improve Utero-Placental Perfusion in Mice. PLoS One. 2016 Oct 13;11(10):e0164353. doi: 10.1371/journal.pone.0164353. PMID: 27736914


Burke SD. Zsengeller ZK, Khankin EV, Lo AS, Rajakumar A, Dupont JJ, McCurley A, Moss ME, Zhang D, Clark CD, Wang A, Seely EW, Kang PM, Stillman IE, Jaffe IZ, Karumanchi SA. Soluble fms-like tyrosine kinase 1 promotes angiotensin II sensitivity in preeclampsia. J Clin Invest. 2016 Jun 6. pii: 83919. doi: 10.1172/JCI83918. PMID: 27270170


Quicke KM, Bowen JR, Johnson EL, McDonald CE, Ma H, O’Neal JT, Rajakumar A, Wrammert J, Rimawi BH, Pulendran B, Schinazi RF, Chakraborty R, Suthar MS. Zika Virus Infects Human Placental Macrophages. Cell Host Microbe. 2016 May 26. pii: S1931-3128(16)30211-6. doi:10.1016/j.chom.2016.05.015. [Epub ahead of print] PMID: 27247001


Wang A, Zseengeller ZK, Hecht JL, Buccafusca R, Burke SD, Rajakumar A, Weingart E, Yu PB, Salahuddin S, Karumanchi SA. Excess placental secreted frizzled-related protein 1 in maternal smokers impairs fetal growth. J Clin Invest. 2015 Sep 28. pii: 80457. doi: 10.1172/JCI80457. [epub ahead of print] PMID: 26413870


Chiuppesi F, Wussow F, Johnson E, Bian C, Zhuo M, Rajakumar A, Barry PA, Britt WJ, Chakraborty R, Diamond DJ. Vaccine-Derived Neutralizing Antibodies to the Human Cytomegalovirus gH/gL Pentamer Potently Block Primary Cytothrophoblast Infection. J Virol. 2015 Sep 16. pii: JVI.0171-15 [Epub ahead of print] PMID: 26378171


Ghosh CC, Thamm K, Berghelli AV, Schrimpf C, Maski MR, Abid T, Milam KE, Rajakumar A, Santel A, Kielstein JT, Ahmed A, Thickett D, Wang K, Chase M, Donnino MW, Aird WC, Haller H, David S, Parikh SM. Drug Repurposing Screen Identifies Foxo1-Dependent Angiopoietin-2 Regulation in Sepsis. Crit Care Med. 2015 July;43(7):e230-40. doi: 10.1097/CCM. 0000000000000993. 2015 Apr 8. [Epub ahead of print] PMID: 25855898


de Carvalho Cavalli R, Cerdeira AS, Korkes H, Burke S, Rajakumar A, Bhasin M, Karumanchi SA, Kopcow H. [31-OR]: Modeling an NK cell based immunotherapy for preeclampsia. Pregnancy Hypertens. 2015 Jan;5(1):15. doi: 10.1016/j.preghy.2014.10.035. Epub 2015 Feb 23. PMID: 25787381 


Rana S, Rajakumar A, Geahchan C, Salahuddin S, Cerdeira AS, Burke SD, George E, Granger J, Ananth Karumanchi S. [27-OR]: Ouabain inhibits placental sFlt1 production by repressing HSP27 dependent HIF-1α pathway. Pregnancy Hypertens. 2015 Jan;5(1):13. doi: 10.1016/j.preghy.2014.10.031. Epub 2015 Feb 23. PMID: 25787376


Weissgerber TL, Rajakumar A, Myerski AC, Edmunds LR, Powers RW, Roberts JM, Gandley RE, Hubel CA. Vascular Pool of Releasable Soluble VEGF Receptor-1 (sFLT1) in Women with Previous Preeclampsia and Uncomplicated Pregnancy. J Clin Endocrinol Metab. 2013 Dec 10:jc20133277. [Epub ahead of print] PMID:24423299


Sofia-Cerdeira A, Rajakumar A, Royle CM, Lo A, Husain Z, Thadhani RI, Sukhatme VP, Karumanchi SA, Kopcow HD. Conversion of peripheral blood NK cells to a decidual NK-like phenotype by a cocktail of defined factors. Jnl of Immunology 2013 J Immunol. 2013 Apr 15;190(8):3939-48. doi: 10.4049/jimmunol.1202582. Epub 2013 Mar 13. PMID: 23487420


Buurma AJ, Penning ME, Prins F, Schutte JM, Bruijn JA, Wilhelmus S, Rajakumar A, Bloemenkamp KW, Karumanchi SA, Baelde HJ Preeclampsia Is Associated With the Presence of Transcriptionally Active Placental Fragments in the Maternal Lung.. Hypertension. 2013 Jul 1. [Epub ahead of print] PMID:23817495


Govender N, Naicker T, Rajakumar A, Moodley J. Soluble fms-like tyrosine kinase-1 and soluble endoglin in HIV-associated preeclampsia. Eur J Obstet Gynecol Reprod Biol. 2013 Jun 24. doi:pii: S0301-2115(13)00252-2. 10.1016/j.ejogrb.2013.05.021. [Epub ahead of print]PMID:23806447


Holwerda, KM., Bos, EM., Rajakumar, A., Ris-Stalpers, C., van Pampus MG., Timmer, A., Erwich, JJ., Faas, MM., van Goor H., Lely, AT. Hydrogen sulfide producing enzymes in pregnancy and preeclampsia. Placenta 2012 (Epub ahead of print) PMID: 22391326


Rajakumar, A., Cerdeira, AS., Rana, S., Zsengeller, Z., Edmunds, L., Jeyabalan, A., Carl A. Hubel, CA., Stillman, IE., Parikh, SM., S. Ananth Karumanchi. SA. Transcriptionally active syncytial aggregates in the maternal circulation may contribute to circulating sFlt1 in preeclampsia. Hypertension, 2012. Feb;59(2): 256-64. PMID:22215706


Wenzel K, Rajakumar A, Haase H, Geusens N, Hubner N, Schulz H, Brewer J, Roberts L, Hubel CA, Herse F, Hering L, Qadri F, Lindschau C, Wallukat G, Pijnenborg R, Heidecke H, Riemekasten G, Luft FC, Muller DN, Lamarca B, Dechend R. Angiotensin II Type 1 Receptor Antibodies and Increased Angiotensin II Sensitivity in Pregnant Rats. Hypertension. 2011 Jul;58(1):77-84. PMID: 21576625


Lin C, Rajakumar A, Plymire DA, Verma V, Markovic N, Hubel CA. Maternal endothelial progenitor colony-forming units with macrophage characteristics are reduced in preeclampsia. Am J Hypertens. 2009,22(9): 1014-19. PMID: 19498340.


Von Versen-Hoynck, F., Rajakumar A., Bainbridge, SA., Gallagher, MJ, Roberts JM and Powers, RW. Human placental adenosine receptor expression is elevated in preeclampsia and hypoxia increases the expression of the A(2A) receptor. Placenta 2009Mar 18 PMID 19303140


Von Versen-hoynck, F, Rajakumar A, Parrott MS, and Powers RW. Leptin affects system A amino acid transport activity in the human placenta: Evidence for STAT3 dependent mechanisms. Placenta 2009 Apr 30 (4) 361-367. PMID 19203792.


Rajakumar, A., Robert W. Powers, RW., Carl A. Hubel, CA., Eiji Shibata, E., von Versen- Hoynck, F., Plymire, D and Jeyabalan, A. Novel soluble Flt-1 isoforms in plasma and cultured placental explants from normotensive pregnant and preeclamptic women. Placenta 30, p25- 34, 2009.


Shibata, E., Powers, RW., Hubel, CA., Rajakumar, A., von Versen-Hoynck, F. and Roberts, JM. Placental system A transport activity is decreased in pregnancies with SGA infants but not preeclampsia with and without SGA infants. Placenta, 29 (10) p879-882, 2008.


Gandley, RE., DiCianno, J., Rajakumar, A., Shibata, E., Hagen, H and Hubel, CA. Myeloperoxidase levels are increased in placenta and circulation of women with preeclampsia. Hypertension 2008, 52 (2): 387-393.


Jeyabalan, A., McGonigal, S., Hubel, CA and Rajakumar, A. Circulating and placental endoglin concentrations in pregnancies complicated by intrauterine growth restriction and preeclampsia. (Placenta 2008, 29, 555-569. PMID:18462791).


Rajakumar, A., Michael, HM., Daftary, A., Jeyabalan, A., Gilmour, C and Conrad, KP. 
Proteasomal activity in placentas from women with preeclampsia and intrauterine growth 
restriction: implications for expression of HIF-á proteins Placenta 29; p290-299, 2008.


Bdolah, Y., Lam, C., Rajakumar, A., Venkatesha, S., Mutter, W., Sacks, B., 
Lim, KH., Epstein, F and Karumanchi, SA. Preeclampsia in twin pregnancies: Hypoxia or 
bigger placental mass? Am Jnl Obstet Gynecol 198 (4) p428, 2008.


Rajakumar., A., Jeyabalan, A., Markovic,N., Ness, R., Gilmour, C and Conrad, KP. Placental 
HIF1-á, HIF2-á, membrane and soluble VEGF receptor-1 proteins are not increased in normotensive pregnancies complicated by late-onset intrauterine growth restriction. Am J Physiol Integr Comp Physiol 2007 293:p766-774.


Hubel CA, Wallukat G, Wolf M, Herse F, Rajakumar A, Roberts JM, Markovic N, Thadhani R, Luft FC, Dechend R. Agonistic angiotensin II type 1 receptor autoantibodies in postpartum women with a history of preeclampsia. Hypertension. 2007 Mar; 49(3):612-7.


Laivuori H, Gallaher MJ, Collura L, Crombleholme WR, Markovic N, Rajakumar A, Hubel CA, Roberts JM, Powers RW. Relationships between maternal plasma leptin, placental leptin mRNA and protein in normal pregnancy, pre-eclampsia and intrauterine growth restriction without pre-eclampsia. Mol Hum Reprod. 2006 Sep; 12(9):551-6.


Shibata E, Powers RW, Rajakumar A, von Versen-Hoynck F, Gallaher MJ, Lykins DL, Roberts JM, Hubel CA. Angiotensin II decreases system A amino acid transporter activity in human placental villous fragments through AT1 receptor activation. Am J Physiol Endocrinol Metab. 2006 Nov; 291(5):E1009-16.


Rajakumar, A., Doty, K., Daftary, A., Markovic, N and Conrad, KP. Expression of von Hippel Lindau (pVHL) protein in placentae from normal pregnant women and women with preeclampsia. Placenta 2006, 27(4-5) p 411-421.


Rajakumar, A., Brandon, HM., Rajakumar, PA., Shibata, E., Hubel, CA., Karumanchi, SA., Thadhani, R., Wolfe, M., Harger, G., and Markovic, N. Extra-placental Expression of Vascular Endothelial Growth Factor Receptor-1, (Flt-1) and soluble Flt-1, (sFlt-1) by Peripheral Blood Mononuclear Cells (PBMCs) in Normotensive and Preeclamptic Pregnant Women. Placenta 2005, 26 (7), p 563-573.


Shibata, E., Rajakumar, A., Powers, RW., Larkin, RW., Gilmour,C., Bodnar,LM., Crombleholme, WR., Ness, RB., Roberts, JM and Hubel, CA. Soluble fms-like Tyrosine Kinase 1 (sFlt-1) is increased in Preeclampsia but not in IUGR Pregnancies Without Preeclampsia: Relationship to Circulating Placental Growth Factor (PlGF). Jnl Clin Endocrin Metabol. 2005 90 (8), 4895-4903.


Wolf, M., Hubel, CA., Lam, C., Sampson, M., Ecker, JL., Ness, RB., Rajakumar, A., Daftary, A., Seely, EW., Roberts, JM., Karumanchi, SA., and Thadhani, R. Preeclampsia and future cardiovascular disease: Potential role of altered angiogenesis and insulin resistance. J Clin Endocrinol Metab. 2004 Dec; 89 (12): 6239-43.


Rajakumar, A., Thamotharan, S., Raychaudhuri, N., Menon, R and Devaskar. SU. Trans- activators Regulating Neuronal Glucose Transporter Isoform-3 Gene Expression in Mammalian Neurons. J. Biol Chem. (2004) 279 (25) p 26768-26779.


Rajakumar, A., Brandon, HM., Daftary, A., Ness, R., and Conrad, KP. Evidence for the functional activity of hypoxia inducible transcription factors over expressed in preeclamptic placentae. Placenta (2004 ) 25 (10) 763-769.


Novak J., Rajakumar A., Miles TM., and Conrad KP. Nitric oxide synthase isoforms in the rat kidney during pregnancy. (2004) Jnl Soc Gyn Inves. Vol 11/5 pp280-288


Rajakumar. A, Ketah Doty, Ashi Daftary, Gail Harger and Kirk P. Conrad. Impaired Oxygen dependent Reduction of HIF-1á and -2á proteins in Preeclamptic Placentae. Placenta. 24, 199-208, 2003.


Rajakumar, A., Kerry A. Whitelock, Ashi R. Daftary, Nina Markovic and Kirk P. Conrad (2001). Selective overexpression of the hypoxia inducible transcription factor, HIF-2á, in placentas from women with preeclampsia. Biology of Reproduction, 64,499-506. Erratum 2001, 64, 1019-1020.


C.O. Quinn, A. Rajakumar and O.A. Agapova. Parathyroid hormone induces rat interstitial collagenase through Ets-1 facilitated by cyclic AMP response element-binding protein and Ca2+/calmodulin-dependent protein kinase II in osteoblastic cells. Jnl of Mol. Endocrin. (2000) 25,73-84.


Rajakumar, A. and Kirk P. Conrad (2000) Expression, ontogeny and regulation of hypoxia inducible transcription factors in the human placenta. Biology of Reproduction, 63,559-569.


JY Khan, A Rajakumar, RA McKnight, UP. Devaskar and SU Devaskar. Effect of congenital Primary Hypothyroidism Upon Expression of Genes Mediating Brain Glucose Uptake. Pediatric Res. (1999). 45: 718-25


JY Khan, A Rajakumar, RA McKnight, UP Devaskar, SU Devaskar. Developmental regulation of genes mediating murine brain glucose uptake. Am J Physiol, 45:892-900, 1999.


A. Rajakumar, Shanthie Thamotharan, Ram K. Menon, and Sherin U. Devaskar. Sp1 and Sp3 regulate transcriptional activity of the facilitative glucose transporter isoform-3 gene in mammalian neuroblasts and trophoblasts. J Biol Chem, 273:27474-27483, 1998.


Sherin U. Devaskar, Claudia Ollesch, A. Rajakumar and Premeela A. Rajakumar. Developmental changes in ob gene expression and circulating leptin peptide concentrations. BBRC 1997, 238:44-47.


A. Rajakumar and Cheryl O. Quinn. Parathyroid hormone induction of rat interstitial collagenase mRNA in osteosarcoma cells is mediated through an AP-1 binding site. Molec. Endo, 1996, 10, p.867.


Rajakumar, A., , Swierkosz, EM. and Schulze, IT. Sequence of an influenza virus Hem- agglutinin determined directly from clinical sample. Proc. Natl. Acad. Sci. Vol. 87, p. 4154- 4158, 1990.


Premeela, T., Rajakumar, A., and Shanmugam, G. Endonucleolytic cleavage of E. coli and pBR 322 DNAs by a placental DNA binding protein. Biochem International 14, p 911-919 (1987).


Rajakumar, A and Shanmugam, G. Dimethyl sulfoxide stimulates the phosphorylation of two major DNA binding proteins of Yoshida Ascites tumor cells. Current Science 55, p 444-446 (1986).


Rajakumar, A, and Shanmugam, G. DNA binding proteins of rat thigh muscle: Purification and characterization of an endonuclease. Journal of Biosciences 10, p 85-94 (1986).


Shanmugam, G., Rajakumar, A, Premeela, T and David, E. DNA binding proteins of Eukaryotic cells. Current Trends in Life Sciences XII Biological Macromolecules p 131-134 (1984).


Premeela,T., Rajakumar, A. and Shanmugam, G. DNA binding proteins of human placenta: Purification and characterization of an endonuclease. Mol. Biol. Reports 10, p 91-97 (1984).


Rajakumar, A. and Shanmugam, G. Endonucleolytic cleavage of pBR322 DNA by a Yoshida Ascites cell DNA-binding protein. Cell Biology International Reports 8, p 561-565 (1984).


Rajakumar, A. and Shanmugam, G. Isolation and characterization of DNA binding proteins 
of Yoshida Ascites tumor cells. Exper. Cell Research 147, p 119-125 (1983). 


Book Chapters

Schulze, I. T., Aytay, S., Rajakumar, A., Stewart, A. R., and Manger, I. D. Hemagglutinin 
polymorphism and Influenza virus host range. (1992) Book Chapter published in Virus
Strategies by Verlag Chemie.


Rajakumar, A., Inkster, I., Manger, ID., Swierkosz, EM., and I. T. Schulze. The use of 
Polymerase Chain Reaction in Influenza virus detection and characterization. Book Chapter 20, Frontiers in Virology, vol 1 (Diagnosis of the human viruses by PCR technology) 1992 Springer-Verlag, Berlin, Heidelbergh.



Selected Poster and Oral Presentations

Rana, S., Rajakumar, A., Geahchan, C., Salahuddin, S., Cerdeira, AS., Burke, SD., George, E., Granger, J., and Karumanchi, SA. Ouabain downregulates sFlt1 production by inhibiting HSP27-dependent HIF-1alpha protein Expression. SGI, 61st Annual Meeting, Florence, Italy. March 26-29, 2014


Burke, SD., Rajaumar, A., Wang, A., Kang, PM., and Karumanchi, SA. Hemodynamic response to Ang II in preeclamptic mice. SGI, 61st Annual Meeting, Florence, Italy. March 26-29, 2014.


Nadkarni, N., Rajakumar, A.,Krishnan, R., Stossel, T., Karumanchi, SA. Plasma gelsolin as as endogenous inhibitor of syncytiotrophoblastmicroparticle shedding in pregnancy, 2014.


Hubel, CA., Powers, RW., Edmunds LR., Myerski A., Weissgerber T., Roberts JM., Gandley RE., Rajakumar, A. Vascular Pool of ReleasableSoluble VEGF Receptor-1 (sFlt-1) Revealed After Intravenous Heparin. SGI 59th Annual meeting, San Diego, CA. March 16-19, 2012.


Rajakumar, A et al., Placental syncytiotrophoblast debris may contribute to circulating sFlt1 in preeclampsia. SGI 58th Annual Meeting, Miami, FL, 2011.


Rajakumar, A. Sources and Mechanisms of sFlt-1 expression in preeclampsia. SGI 57th Annual meeting, Orlando, FL, 2010.


Rajakumar, A. Sources and Mechanisms of sFlt-1 expression in preeclampsia. Tox Talks, San Francisco, 2009.


Rajakumar, A, Tianjiao, C., Handley, D., Bunce, K., Burke, B., Jeyabalan, A., Hubel, C., Roberts, J., and Peters, D. Maternal gene expression profile during normal pregnancy and preeclampsia using human peripheral blood mononuclear cells. SGI 56th Annual Meeting, Glasgow, Scotland, 2009.


Von Versen-Hoeycnk, F., Rajakumar, A., Roberts, J., and Powers, R. Adenosine receptor expression is higher in placentas of women with preeclampsia. SGI 56th Annual Meeting, Glasgow, Scotland, 2009.


Von Versen-Hoeycnk, F., Rajakumar, A., Parrott, M., Roberts, J., and Powers, R. Leptin affects system A amino acid transport activity in the human placenta. Evidence for STAT3 dependent mechanisms. SGI 56th Annual Meeting, Glasgow, Scotland, 2009.


Rajakumar, A., Powers, R., Hubel, C., Shibata, E., Eiji Shibata, Von Versen-Hoeynck, F., Plymire, D., Jeyabalan, A. Novel and distinct isoforms of sFlt-1 are present in higher amounts in plasma of women with preeclampsia. ISSHP international conference, Washington DC, 2008.


Rajakumar. A., McGonigal, S., Daftary, A., Jeyabalan, A. Intrauterine Growth Restriction at term is not associated with higher concentrations of Placental or circulating Endoglin. 13th International Federation of Placenta Associations and Placenta Associations of the Americas, Ontario, Canada, 2007.


Rajakumar, A., Powers, R., Hubel, C., Shibata, E., Eiji Shibata, Von Versen-Hoeynck, F., Plymire, D. Plasma from preeclamptic women shows 2007 additional soluble variants. 13th International Federation of Placenta Associations and Placenta Associations of the Americas, Ontario, Canada, 2007.


Rajakumar, A., Conrad, KP., Gandley, R., Dechend, R., and Hubel C. Non-hypoxic regulation of HIF proteins in normal and preeclamptic placentas. 13th International Federation of Placenta Associations and Placenta Associations of the Americas, Ontario, Canada, 2007.


Jeyabalan A, Rajakumar A, McGonigal S, Markovic N, Hubel C, Morris SM. Arginase activity is increased in HELLP syndrome but not in preeclampsia at term. North American Society of Hypertension in Pregnancy, San Diego, CA, 2007.


Jeyabalan A, Rajakumar A, McGonigal S, Markovic N, Hubel C, Morris SM. Placental arginase II is increased in preeclampsia but not with intrauterine growth restriction at term. North American Society of Hypertension in Pregnancy, San Diego, CA, 2007.


Jeyabalan A., McGonigal, S., Gail Harger, G., Daftary, A.,Rajakumar, A. Placental Endoglin Levels are increased in Preeclampsia but not in Pregnancies Complicated by Intrauterine Growth Restriction. 53rd Annual SGI meeting, Reno, Nevada, 2007.


Carol Lin, Augustine Rajakumar, Vivek Verma, Nina Markovic, Roberta Ness, Daniel Plymire, Carl Hubel. Clonogenic Endothelial Progenitor Cells Are Decreased in Women with Preeclampsia. 53rd Annual SGI meeting, Reno, Nevada, 2007.


Augustine Rajakumar, Eiji Shibata, Frauke Von Versen-Hoeynck, Daniel Plymire, Ashi Daftary, Robert Powers, Carl Hubel. Identification of Antigenically Distinct, Hypoxia Responsive sFlt isoforms in Conditioned Media of Explants Culture and in Plasma from Normptensive and Preeclamptic Women. 53rd Annual SGI meeting, Reno, Nevada, 2007.


Frauke Von Versen-Hoeynck, Augustine Rajakumar, James M. Roberts, Nina Markovic, Robert Powers. Acute Hypoxia Decreases System A Amino Acid Transporter Activity in Placental Villous Explants. 53rd Annual SGI meeting, Reno, Nevada, 2007.


Frauke Von Versen-Hoeynck, Augustine Rajakumar, James M. Roberts, Gail Harger, Robert Powers. Adenosine Reduces System A Amino Acid Transporter Activity in Placental Villous Explants. 53rd Annual SGI meeting, Reno, Nevada, 2007.


Frauke Von Versen-Hoeynck, Augustine Rajakumar, James M. Roberts, Nina Markovic, Robert Powers. Leptin Does (not) Alter Placental System A Amino Acid Transporter Activity But Activates its Receptors. 53rd Annual SGI meeting, Reno, Nevada, 2007.


Robin E. Gandley, Jennifer Rohland, Yan Zhou, Eiji Shibata, Augustine Rajakumar, Valerian Kagan, Susan J. Fisher and Carl A. Hubel. Increased myeloperoxidase in the placenta and circulation of women with preeclampsia. 15th World Congress International Society for the Study of Hypertension in Pregnancy (ISSHP), Lisbon, Portugal, 2006.


H. Laivuori, M.J. Gallaher, L. Collura, W.R. Crombleholme, N. Markovic, A. Rajakumar, C.A. Hubel, J. M. Roberts and R.W. Powers. Relationship between placental leptin expression, placental leptin protein and maternal plasma leptin in normal pregnancy, pre-eclampsia and intrauterine growth restriction without pre-eclampsia. 15th World Congress International Society for the Study of Hypertension in Pregnancy (ISSHP), Lisbon, Portugal, 2006.


Eiji Shibata, Robert W. Powers, Carl A. Hubel, Augustine Rajakumar, Frauke von Versen-Hoynck and James M. Roberts. Placental system A transport activity is decreased in pregnancies with SGA infants but not preeclampsia with and without SGA infants. 53rd Annual SGI meeting, Toronto, Ontario, 2006.


Augustine Rajakumar, Arun Jeyabalan, Nina Markovic, Roberta Ness and Kirk P. Conrad. HIF-a proteins and downstream genes, Flt-1 and sFlt-1, in normal pregnant, preeclamptic and IUGR placentas. 53rd Annual SGI meeting, Toronto, Ontario, 2006.


Robin E. Gandley, Jennifer DiCianno, Eiji Shibata, Augustine Rajakumar, Valerian Hagen and Carl Hubel. Myeloperoxidase levels are increased in placenta and circulation of women with preeclampsia. 53rd Annual SGI meeting, Toronto, Ontario, 2006.


Yuval Bdolah, Chun Lam, Augustine Rajakumar, Shivalingappa Venkatesha, Walter Mutter, Benjamin Sacks, Kee-Hak Lim, Franlklin Epstein,
2006 and Ananth Karumanchi. Preeclampsia in twin pregnancies: Hypoxia or bigger placental mass? 53rd Annual SGI meeting, Toronto, Ontario, 2006.


Augustine Rajakumar, Arun Jeyabalan, Heather M. Michael, Ashi Daftary,
 Gail Harger and Kirk Conrad. Placentas from women with preeclampsia and intrauterine growth restriction exhibit deficient proteasomal activity. 53rd Annual SGI meeting, Toronto, Ontario, 2006.


Augustine Rajakumar, Extra-placental soluble Flt, sFlt by PBMCs in preeclampsia. NASSHP meeting, Wheeling, WV, 2005.


Augustine Rajakumar, Hypoxia and soluble Flt: Implications in Preeclampsia. Beth Israel Hospital, Harvard Medical School, Boston MA, 2005.


Augustine Rajakumar, Mechanisms of pathogenesis of preeclampsia: 1)
 Deficient proteasomal function in placentas of preeclamptic women and 2) sFlt by peripheral blood mononuclear cells. Tox Talks, San Francisco CA, 2005.


Augustine Rajakumar, H.M. Michael, A. Daftary, R. Ness and K.P. Conrad.
 The proteasomal inhibitor, clasto-lactacystin, reverses the defect in HIF-1a protein degradation in preeclamptic placentas. 52nd Annual SGI meeting, Los Angeles, CA, 2004.


E. Shibata, C.A. Hubel, R.W. Powers, A. Rajakumar, and J. M. Roberts.
 Angiotensin II Type 1 Receptor Activation Reduces System A Amino Acid Transort in Human Placental Villi, 2004.


E. Shibata. A. Rajakumar, R.W. Powers, R.W. Larkin, C. Gilmour, W. R. Crombleholme, R. B. Ness, J. M. Roberts, and C. A. Hubel. Soluble fms-like Tyrosine Kinase 1 (sFlt-1) and placental growth factor (PlGF) expression in Preeclampsia and small for gestational age pregnancies. The 14th world congress of the international society for the study of hypertension in
pregnancy, and US National Institute of Child Health and Development
Award presentation, Vienna, Austria, 2004.


Eiji Shibata, Carl Hubel, Robert Powers, Augustine Rajakumar, Marcia Gallagher, Joseph Tucker and James Roberts. Angiotensin II (ANG II) type 1
receptor (AT1-R) activation reduces system A amino acid transport in human placental villi. 52nd Annual SGI meeting, Los Angeles, CA, 2004.


Augustine Rajakumar, Heather M. Brandon, Premeela A. Rajakumar, Eiji Shibata, Carl A. Hubel, Ananth Karumanchi, Ravi Thadhani, Myles Wolf, Gail Harger, Nina Markovic. Peripheral blood mononuclear cells (PBMCs) of pregnant women are the potential extra-placental source of soluble VEGF receptor, sFlt contributing to preeclampsia: Regulation by hypoxia. Placenta Association of the Americas, Asilomar CA, 2004.


Augustine Rajakumar, Heather M. Brandon, Premeela A. Rajakumar, Eiji Shibata, Carl A. Hubel, Ananth Karumanchi, Ravi Thadhani, Gail Harger, Nina Markovic. Differential Expression of Vascular Endothelial Growth Factor Receptor, Flt-1 in PBMCs of Pregnant Women. 51st Annual SGI meeting, Houston, Texas, 2004.


Carl A. Hubel, Myles Wolf, Augustine Rajakumar, Ashi Daftary, James M. Roberts, Roberta Ness, Ananth Karumanchi and Ravi Thdhani. An Excess of Serum Soluble FMS-like Tyrosine Kinase-1 (sFlt) Persists Postpartum in Women with Prior Preeclampsia: Relation to Insulin Resistance. 51st Annual SGI meeting, Houston, Texas, 2004.